ESBL positive and Carbapenemases positive Enterobacteriaceae (CPE) have now become a global concern. CPE are often express MDR and XDR phenotypes with increasing reports of pan-resistance. The spread of ESBLs is regions of low resistance and KPC, MBLs and OXA-48/181 in regions where ESBLs are established impact on therapeutic failure and increase morbidity.
Therefore, the implementation of a rapid and accurate assessment to detect antibiotic resistance mechanisms in Gram-negative pathogens is essential. To evaluate various Liofilchem® MTS in detecting extended-spectrum β-lactamases (ESBLs) and carbapenemases [metallo-β-lactamases (MBLs) and OXA-48 (and OXA-181)]. Five centres across Europe and one in Russia tested the MTS against in-house methods.
|Determination of the sensitivity and specificity of the MIC Test Strips (MTS) mechanisms of detection against in-house methods for 644 multi-drug resistant (MDR) strains: a European multi-centre study|