– The incidence of infections with multidrug resistant (MDR) Enterobacteriaceae has risen considerably in recent years, associated mostly with ESBL production.
– Tigecycline is a glycylcycline antibiotic that shows good activity against most MDR Enterobacteriaceae and is therefore frequently used in infections with ESBL or carbapenemase producers [1].
– Conflicting data exist on the validity of susceptibility data generated by different susceptibility testing methods [2, 3].
– We therefore compared three different commercial methods to the current gold standard using a set of molecularly characterized E. coliand K. pneumoniaeisolates from invasive infections.
| Comparison of four methods for the determination of tigecycline susceptibility in multi-resistant E. coli and K. pneumoniae |